Homocysteine is a risk factor for Alzheimer’s disease. In the first report of a trial, researchers showed that homocysteine-lowering treatment with B vitamins slows the rate of brain atrophy in mild cognitive impairment (MCI). This was a double-blind, single-centre study, which included participants with MCI, aged 70 years and older, randomly assigned to receive a daily dose of 0.8 mg folic acid, 0.5 mg vitamin B12 and 20 mg vitamin B6 (133 participants) or placebo (133 participants) for 2 years. There was significant benefit of B-vitamin treatment among participants with baseline homocysteine above the median. In this small intervention trial, B vitamins appear to slow cognitive and clinical decline in people with MCI, in particular in those with elevated homocysteine.
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